Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00056 |
Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)
ATX II,Delta-AITX-Avd1c,... |
Anemonia sulcata | P. pastoris (Yeast) |
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured... |